Publications

For a full list of Dr. Hancks’ publications, click here.

January 15, 2026

Nucleotide metabolic rewiring enables NLRP3 inflammasome hyperactivation in obesity

Liu D, Zhou C, Wang X, Luo Z, Xu R, Huo S, Guo L, Luo X, Yang S, Click A, Vancil J, Barajas P, Mijares V, Baniasadi H, Yan N, Rehwinkel J, Hancks DC, Chen EH, Liang S, Zhong Z. Nucleotide metabolic rewiring enables NLRP3 inflammasome hyperactivation in obesity. Science. 2026 Jan 15;391(6782):eadq9006. doi: 10.1126/science.adq9006. Epub 2026 Jan 15. PMID: 41538457; PMCID: PMC13034487.

Pubmed | PDF

September 25, 2025

A subclass of small RNAs is encoded by exons of protein-coding genes

Chang, T., Hancks, D.C*. A subclass of small RNAs is encoded by exons of protein-coding genes. BMC Genomics 26, 827 (2025). https://doi.org/10.1186/s12864-025-11982-3 PMID: 41013174 PMCID: PMC12465437

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April 21, 2025

Viral piracy of host RNA phosphatase DUSP11 by avipoxviruses

Szymanik KH, Rex EA, Pothireddy VR, Gammon DB, Hancks DC*, Sullivan CS* (2025) Viral piracy of host RNA phosphatase DUSP11 by avipoxviruses. PLoS Pathog 21(4): e1013101. https://doi.org/10.1371/journal.ppat.1013101

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December 03, 2024

An evolutionary framework exploiting virologs and their host origins to inform poxvirus protein functions.

Hancks, D.C. (2025) An evolutionary framework exploiting virologs and their host origins to inform poxvirus protein functions. Vaccinia, Mpox, and Other Poxviruses: Methods and Protocols, Methods in Molecular Biology, 2025:2860:257-272. doi: 10.1007/978-1-0716-4160-6_17. PMID: 39621273.

Pubmed

October 30, 2024

Metabolic reprogramming tips vaccinia virus infection outcomes by stabilizing interferon-γ induced IRF1

Chang, T.C.*, Alvarez, J.*, Chappidi, S., Crockett, S., Sorouri, M., Orchard, R.C., Hancks D.C. (2024) Metabolic reprogramming tips vaccinia virus infection outcomes by stabilizing interferon-y induced IRF1. PLOS Pathogens. doi: https://doi.org/10.1101/2024.10.10.617691. Oct 30;20(10):e1012673. doi: 10.1371/journal.ppat.1012673. PMID: 39475961 PMCID: PMC11554218.

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March 29, 2023

Norovirus MLKL-like pore forming protein initiates programed cell death for viral egress

Wang, G., Zhang, D., Orchard, R., Hancks, D.C.*, Reese, T.A.* (In Press) Norovirus MLKL-like pore forming protein initiates programed cell death for viral egress. Nature. DOI: 10.1038/s41586-023-05851-w PMID: 36991121; bioRxiv preprint PMID: 36993770 PMCID: PMC10055165 DOI: 10.1101/2023.03.17.533118.

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December 9, 2021

Evolutionary Profile for (Host and Viral) MLKL Indicates Its Activities as a Battlefront for Extensive Counteradaptation

Palmer SN, Chappidi S, Pinkham C, Hancks DC. Mol Biol Evol. 2021 Dec 9;38(12):5405-5422. doi: 10.1093/molbev/msab256. PMID: 34436583

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December 28, 2020

Signatures of host-pathogen evolutionary conflict reveal MISTR-A conserved MItochondrial STress Response network

Sorouri M, Chang T, Jesudhasan P, Pinkham C, Elde NC#, Hancks DC#. PLoS Biol. 2020 Dec 28;18(12):e3001045. doi: 10.1371/journal.pbio.3001045. eCollection 2020 Dec. PMID: 33370271 #Co-senior Author

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